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COMMENT PAGE FOR:
URI Taurine and aging: Is there anything to it?
_xerces_ wrote 28 min ago:
I was taking taurine 1000 mg per day but stopped when I heard a
plausible link to colon cancer. Having a strong family history, it
wasn't worth the risk.
Eagerly awaiting the results of this trial: [1] Uncertain though how
they will separate the effects of the taurine from all the other stuff
including sugar that is contained in energy drinks.
I think this is a hard theory to pin down as it might depend on how
much taurine producing bacteria an individual has in their gut B.
wadsworthia, so two people could have very different outcomes while
taking the same amount of taurine.
URI [1]: https://ascopubs.org/doi/10.1200/JCO.2024.42.16_suppl.TPS3630
jbentley1 wrote 51 min ago:
Read the first couple lines, closed the page, and concluded that I
should drink more Red Bull.
robwwilliams wrote 1 hour 24 min ago:
The original taurine paper in Science was obviously a mess to some of
us in the field. They did not even have plausible taurine
concentrations. Poor review process.
There is no reason to supplement with taurine or with resveratrol.
Resveratrol debunked firmly by both the Interventions Testing Program
in mice (Miller et al 2011, a paper with Sinclair as a coauthor) and
earlirr by Timothy Bass and Linda Partridge and colleagues in two
widely used model organisms (C elegans anf Drisophila, 2007).
Yes David Sinclair is vocal and has a book: but look at the evidence
and compare to rapamycin.
Rapamycin is a drug with strong prolongevity effects at almost any age
in both sexes at an appropriate dose to inhibit only mTOR-C1 signaling
(4 to 8 mg once per week).
There ARE side effects to almost any drug. And rapamycin will not be a
good drug for a subset of humans in some environments. For example
rapamycin is one if the last drugs I would take if I was caring for a
room full of 5-6 year olds all day. But surprisingly it was a good drug
to be taking during COVID-19 if you were older. perhaps by reducing the
inflammatory hyper-vigilance that killed so many older humans. See
Kaeberleinâs study of 333 biohackers in 2023.
lentoutcry wrote 54 min ago:
what about methylene blue? I saw an article around the other day
saying basically that itâs mostly hype, but Iâve also heard good
things about it.
baxtr wrote 1 hour 26 min ago:
After looking a bit into the longevity stuff Iâve come to the
conclusion that 80% of the benefits for health come from simple habits:
sleep well, move daily, work-out regularly, eat fresh and moderately,
and maintain social connections. Thatâs it.
const_cast wrote 54 min ago:
Oh, and of course genetics. Doesn't matter very much if you have a
genetic pre-disposition to some bad disease and you don't know that.
So, make sure you're getting screened per recommendations!
number6 wrote 50 min ago:
Apparently, the less paperwork you deal with, the longer you live.
Somewhere out there, a 132-year-old is thriving simply because no
one ever processed their birth certificate â and correlational
data suggests that weak administrative systems might just be the
true secret to longevity, sparing people the existential stress of
ever having to file anything at all
valianteffort wrote 1 hour 2 min ago:
There are drugs like metformin which appear to have a drastic affect
on lifespan in patients with or without diabetes.
But yes generally, premature death seems to come from bad lifestyle
choices over a lifetime, so being proactive is gonna yield the
greatest return.
layer8 wrote 1 hour 15 min ago:
Yeah, and I donât expect any new simple solutions to suddenly be
discovered either.
paulcole wrote 1 hour 45 min ago:
> Taurine and Aging: Is There Anything to It?
Remember that you should only smugly refer to Betteridgeâs Law of
Headlines when you disagree with the article.
mark_l_watson wrote 2 hours 8 min ago:
I understand that trying to take supplements to slow aging is a crap
shoot. That said I take Taurine in the form of eating dark chicken
meat, legs and thighs. I also take NAD+ with resveratrol as publicized
by David Sinclair at Harvard.
I believe that the very best thing to do to maintain health and perhaps
have higher quality of life, later in life, is to meditate, forgive
other people and yourself, and generally balance spirituality, good
sleep, good food, and walk outside a few times a day.
EDIT: left off two big things. As we age we need vitamin D supplements
and I personally also believe in loading up on Omega 3 by eating
walnuts, chia seeds, and salmon.
apwell23 wrote 1 hour 31 min ago:
none of that stuff is going to prolong your life
eitally wrote 1 hour 37 min ago:
These are all good life practices but you've forgotten one key
component of mental aging: many individuals' growing lack of
curiosity as they age. Lifelong learning, and generally also contact
with others, is very important to keeping the mind sharp as one gets
older.
mark_l_watson wrote 56 min ago:
I do still write books on AI and tech [1] My Dad lived to almost
102 and he was learning new things right up to the end of his life.
He was a physics professor and Berkeley but in retirement he got
into model trains, organized social activities, and taught himself
3D animation and started writing scripts and got into digital story
telling.
So, I agree with you, always learning new things makes life
interesting and probably has health benefits.
URI [1]: https://leanpub.com/u/markwatson
dwedge wrote 1 hour 41 min ago:
As far as I know there is little if any proven benefit to vitamin D
supplementation, but a lot of links between high vitamin D and good
health markers. Just a reminder that you should try to get some sun
exposure as well for natural vitamin D, as that may well be where the
health benefits really come from
const_cast wrote 52 min ago:
As an aside when it comes to sun and vitamin D: your body will
still produce vitamin D from the sun if you wear sunscreen. You
also get all the mental health benefits like serotonin and whatnot
with sunscreen.
So, if you're a partial sun plant (white person), you should get
sun but you should use sunscreen, and you'll be fine and that will
work.
epgui wrote 1 hour 38 min ago:
Vit D is actually one of the few vitamin supplements that have
proven benefits, if you live far from the equator.
dwedge wrote 1 hour 7 min ago:
Supplemention specifically, or raised vitamin D? This article
suggested otherwise but I haven't followed it up
URI [1]: https://www.outsideonline.com/podcast/inside-rowan-jacob...
kuratkull wrote 1 hour 28 min ago:
Anything you want to share that raises it above all else?
Especially as you agree that all other supplements are basically
snake oil.
layer8 wrote 1 hour 19 min ago:
They are talking about vitamin supplements specifically.
34679 wrote 1 hour 46 min ago:
>crap shoot
Funny you say that:
"It is a major constituent of bile and can be found in the large
intestine. It is named after Latin taurus (cognate to Ancient Greek
ÏαῦÏοÏ, taûros) meaning bull or ox, as it was first isolated
from ox bile in 1827 by German scientists Friedrich Tiedemann and
Leopold Gmelin."
URI [1]: https://en.wikipedia.org/wiki/Taurine
the__alchemist wrote 1 hour 58 min ago:
I've been doing a similar routine + intermittent fasting (Late
breakfast/early dinner) + NMN and metformin. Probably isn't doing
anything useful.
Re vitamin D: I supplement with that as well, but for a tangential
reason: Avoiding sun exposure (esp mid-day) without sunblock avoids
photoaging and reduces skin cancer risk. But this leaves you at a
Vitamin D deficit, hence the supplement.
I have a tub of taurine, but haven't been taking it; seemed like the
evidence was thin, and this article supports that conclusion.
snapplebobapple wrote 25 min ago:
Are you getting enough vitamin k complex? Depending on the D dose
you are taking there are some indications that that might be
important to avoid arterial calcification (among other things).
URI [1]: https://pmc.ncbi.nlm.nih.gov/articles/PMC5613455/
dwedge wrote 1 hour 33 min ago:
It may well be the sun exposure and not the vitamin D that's good
for you
URI [1]: https://www.outsideonline.com/podcast/inside-rowan-jacobse...
the__alchemist wrote 8 min ago:
Wouldn't surprise me. This is a tough nut to crack because it is
likely true, but photo aging and skin cancer are unquestionably
true and negative effects of UV exposure.
todotask2 wrote 1 hour 33 min ago:
Does intermittent fasting apply to those that is underweight?
robwwilliams wrote 1 hour 7 min ago:
Will depend on age and the definition of underweight.
Intermittent fasting is probably generally beneficial to maintain
the health of already healthy humans up to 75 years of age. But
at that age exercise and weights (gently) probably more helpful.
mark_l_watson wrote 1 hour 42 min ago:
Yes, intermittent fasting seems to have good effects. I used to
restrict eating to the period 11am to about 5pm, and I felt better.
Now all I do is to avoid eating any food within three hours of
going to bed. I don't know how reliable my Apple Watch really is,
but my deep sleep ratings are much better when I stop eating after
a light early dinner, and this makes some sense: if you are
actively digesting food your heart rate is probably increased and
generally your body can settle down. As you know, digesting food is
a major activity.
eitally wrote 1 hour 39 min ago:
Science has shown that the best quality sleep is achieved when
core temperature drops about 3 degrees, and this is almost
impossible when one has eaten a meal within an hour or two of
going to bed.
esperent wrote 54 min ago:
Or if you live in a hot country. But that makes me suspicious
of this finding - it should mean that everyone (without AC) in
hot countries sleeps badly. I doubt that to be true though.
kace91 wrote 2 hours 6 min ago:
No anaerobic training? Youâll really want that bone density and
general mobility down the line, and it also helps greatly aligning
the others (pushes you to sleep, eat ealthier, helps with stress etc)
jgilias wrote 2 hours 7 min ago:
Donât forget some type of strength training. Thereâs plenty of
research that it reduces all cause mortality. Likely by pushing back
the time you become frail.
snapplebobapple wrote 31 min ago:
This might get turned on its head in a couple years. Some new
research just came out on combining incretin based therapies (ie
semaglutide) with myostatin blockers (in this case trevogrumab and
garetosmab) and the monkey lost a crap load of fat while also
putting on muscle mass. It's a hell of a time to be a monkey,
hopefully it translates into a hell of a time to be a human in a
few years. Also, I would like some samples of whatever substance
the guys naming these drugs are consuming. Whatever it is, they are
wasting it on naming drugs when they should be using it to write
science fiction.
Spooky23 wrote 1 hour 47 min ago:
Absolutely. I saw this with aging loved ones. The most
âdurableâ ones fared better as they aged and had health issues.
As you age, each acute medical event has a real impact and recovery
is slow and limited. You have to be at an high baseline to crawl
back up.
My dad had a stroke that really affected him badly, but he
recovered a lot and worked hard. It was all set back by a cold and
a uti that resulted in a hospitalization. That basically did him
in. Everything you can do to make sure that you can stand up and
get around as long as possible means that youâll be able to live
a longer fulfilling life.
fny wrote 1 hour 26 min ago:
My grandfather was hit by a car at 80 and only recovered because
he has the constitution of a tank.
Even afterwards he fights daily to do everything himself.
mark_l_watson wrote 1 hour 59 min ago:
I should, but I don't. I do hike four hours a week and swim for a
half hour every day very early in the morning. Thanks for the
reminder, you are 100% correct. I am in my mid 70s, so I think I
only need resistance training about twice a week.
lagniappe wrote 1 hour 50 min ago:
You need it every day at that age to preserve bone density.
apwell23 wrote 1 hour 25 min ago:
actually you need it 3 times a day
dakiol wrote 1 hour 32 min ago:
Need what exactly? Resistance training or strength training? Or
both?
bravesoul2 wrote 1 hour 46 min ago:
Citation?
lentoutcry wrote 2 hours 11 min ago:
this is the first time Iâm hearing taurine had been linked in any way
to aging (while also finding out thatâs no longer supported by
evidence). all I knew was that itâs something energy drinks have. but
Iâm curious, did this take off as a popular supplement?
amelius wrote 2 hours 12 min ago:
Answer from TFA: no
> But taken together, all of this new information makes me glad that I
have not been loading up on the taurine for purposes of graceful aging,
I can tell you that for sure.
meindnoch wrote 2 hours 29 min ago:
A Downside of Taurine: It Drives Leukemia Growth
URI [1]: https://www.urmc.rochester.edu/news/story/a-downside-of-taurin...
john-h-k wrote 1 hour 30 min ago:
This has to be taken as one of many data points. Many things that are
good for your body will also drive increased cancer growth
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